Aug 13

A specific immune-system mechanism underlies the skin rashes caused by contact with nickel, one of the world’s most common allergens.

German researchers have found that in humans, the metal directly activates a member of the family of receptors that act as gatekeepers of innate immunity, the body’s first line of defence against pathogens. Activating this receptor, called Toll-like receptor 4 (TLR4), generates a ‘danger signal’ that promotes inflammation — causing itching, tenderness, swelling and rashes on the skin — and recruits other immune cells such as T cells to the area.

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Tags: Nickel , Nickel Allergy